MEDICINES CO /DE filed this form 10-Q on 15 May 2002
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1.8.        "Intellectual Property Rights" shall mean know how, patents, trade
            marks, service marks, trade names, registered designs, design
            rights, copyright (including rights in computer software) and any
            rights or property similar to any of the foregoing in any part of
            the world whether registered or not registered together with the
            right to apply for the registration of any such rights.

1.9.        "License Agreement" shall mean the License Agreement providing for
            an exclusive license to the Product (as therein defined) by and
            between the Parties, attached hereto as a Schedule 2.

1.10.       "License Agreement Effective Date" shall have the meaning defined in
            Article 9.1.3.

1.11.       "License Agreement Notice" shall have the meaning defined in Article

1.12.       "Party" or "Parties" shall mean TMC and/or ASTRAZENECA.

1.13.       "Person" shall mean an individual, sole proprietorship, partnership,
            limited partnership, limited liability partnership, corporation,
            limited liability company, business trust, joint stock company,
            trust, unincorporated association, joint venture or other similar
            entity or organisation, including a government or political
            subdivision, department or agency of a government.

1.14.       "Pilot Study" shall mean the clinical study to be carried out
            according to the study outline attached hereto as a Schedule 3.

1.15.       "Product" shall mean any pharmaceutical formulation or product for
            intravenous application containing the Compound as the sole active
            ingredient in a finished dosage form suitable for administration to

1.16.       "Results" shall mean any inventions, formulae, products, processes,
            techniques, discoveries, improvements, information, data and
            knowledge developed, generated or reduced to practice under or in
            connection with the Pilot Study and any Intellectual Property Rights
            related thereto.