MEDICINES CO /DE filed this form 10-Q on 15 May 2002
- velhartice.info

            It is explicitly understood and agreed by the Parties that
            ASTRAZENECA shall have no obligations whatsoever to transfer or
            supply, other than as explicitly provided for under Article 2.1, any
            quantity of Compound or Product to TMC.

2.9.        ASTRAZENECA undertakes, upon having received written notice from
            TMC, for a period of three (3) months starting sixty (60) days upon
            ASTRAZENECA's receipt of such TMC's notice, to assist TMC, by
            telephone, e-mail or other appropriate means as agreed by the
            Parties, in TMC's discussions with Fresenius (as defined in the
            License Agreement) in connection with Fresenius' restart of the
            formulation program regarding the Product. Such ASTRAZENECA's
            assistance shall be given to an extent necessary and reasonable and
            shall not, together with any such assistance provided for under
            Article 3.1, 3.2 and 3.5.1 under the License Agreement, exceed in
            total [**]. It is acknowledged that ASTRAZENECA may at its
            discretion carry out any such assistance for up to [**] percent
            ([**]%) of such [**] by using Third Party consultants.

            For any services or assistance performed by ASTRAZENECA pursuant to
            this Article 2.9, TMC shall reimburse ASTRAZENECA for ASTRAZENECA's
            out-of-pocket costs for such activities plus [**] U.S. Dollars
            ($[**]) [**]. Should ASTRAZENECA use a Third Party consultant(s) for
            carrying out assistance for a certain FTE Day, or part thereof,
            then, for the avoidance of doubt, the FTE Day rate now stated shall
            apply thereon, and the out-of-pocket costs for consultants, if any,
            as indicated above in this paragraph, shall apply only to costs for
            consultants which would typically have been incurred should the
            assistance have been actually carried out by an employee(s) of
            ASTRAZENECA or its Affiliates.

            ASTRAZENECA shall invoice TMC for all assistance during each
            relevant time period within thirty (30) days of the expiration of
            each calendar half-year.

            Submission of first draft of the Supply Agreement