10-Q
MEDICINES CO /DE filed this form 10-Q on 15 May 2002
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3.5.4.      TMC shall promptly inform ASTRAZENECA in writing of any Filing of an
            NDA and of any NDA Approval, and shall in immediate connection
            therewith provide ASTRAZENECA with a written summary of any such
            Filing of an NDA and NDA Approval, or with a copy thereof, whichever
            ASTRAZENECA may elect.

3.5.5.      Following NDA Approval in a certain Major Market or other country of
            the Territory TMC shall use its Commercially Reasonable Efforts to
            Launch the Product in such Major Market or other country

3.6.        Marketing and Sales of Product.

3.6.1.      Regarding any country of the Territory where the Product is
            Launched, TMC shall promptly inform ASTRAZENECA writing of the
            occurrence of such Launch.

3.6.2.      TMC shall, in each Major Market or other country of the Territory
            where the Product has been Launched, at its own expense, or the
            expense of its Affiliates, sub-licensees or distributors, use
            Commercially Reasonable Efforts to market and sell the Product.

3.6.3.      For the avoidance of doubt, what is stated regarding the obligations
            of TMC in this Article 3 or elsewhere in this Agreement shall always
            be subject to what is stated in Articles 2.2 and 2.3, such that any
            of TMC's obligations may be performed by one or more of TMC's
            Affiliates or sublicensees. Further, in accordance with what is
            stated in Article 2.4, any of TMC's obligations under this Article
            3.6 and under Article 3.7 may be performed by one or more of TMC's
            distributors.

3.7.        Specific Time Limits for Performance. Notwithstanding what is stated
            in Articles 3.4.2, 3.5.2, 3.5.5 and 3.6.2, and without limiting the
            general performance criteria stated therein, the following
            performance criteria stated in this Article 3.7 shall apply to the
            situations herein described.