MEDICINES CO /DE filed this form 10-Q on 15 May 2002
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            rights back to the assigning Party immediately prior to it ceasing
            to be an Affiliate of the assigning Party.

17.2.       Severance.

17.2.1.     If any provision of this Agreement shall be found by any court or
            administrative body of competent jurisdiction to be invalid or
            unenforceable, such invalidity or unenforceability shall not,
            provided that the general content of the Agreement remains
            substantially the same as prior to such invalidity or
            unenforceability, affect the other provisions of this Agreement
            which shall remain in full force and effect.

17.2.2.     The Parties agree, in the circumstances referred to in Article
            17.2.1, to attempt to substitute for any invalid or unenforceable
            provision a valid or enforceable provision which achieves to the
            greatest extent possible the same effect as would have been achieved
            by the invalid or unenforceable provision.

17.3.       Notices.

17.3.1.     All notices and other communications given or made in relation to
            this Agreement;

17.3.2.     shall be in English and in writing;

17.3.3.     shall be delivered by hand or sent by first class registered post or

17.3.4.     shall be delivered or sent to the Party concerned at the relevant
            address or facsimile number, shown in Article 17.4 subject to such
            amendments as may be notified from time to time in accordance with
            this Article by the relevant Party to the other Party by no less
            than three business days notice; and

17.3.5.     shall be deemed to have been duly given or made if addressed in the
            aforesaid manner;